2026
Rao NR, Santiago-Marrero I, DeGulis O, Nomura T, Goyal K, Lee S, Hark TJ, Dynes JC, Dexter EX, Dulewicz M, Ge J, Upadhyay A, Fornasiero EF, Vassar R, Hanrieder J, Contractor A, Savas JN. Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer’s disease models. Sci Transl Med. 2026 Feb 11;18(836):eadp3984. PDF
2025
Mohar B, Michel G, Wang YZ, Hernandez V, Grimm JB, Park JY, Patel R, Clarke M, Brown TA, Bergmann C, Gebis KK, Wilen AP, Liu B, Johnson R, Graves A, Tchumatchenko T, Savas JN, Fornasiero EF, Huganir RL, Tillberg PW, Lavis LD, Svoboda K, Spruston N. DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning. Nat Neurosci. 2025 May;28(5):1089-1098. (Collaboration)
2024
Bomba-Warczak EK, Velez KM, Zhou LT, Guillermier C, Edassery S, Steinhauser ML, Savas JN, Duncan FE. Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan. Elife. 2024 Oct 31;13:RP93172. (Collaboration) PDF
Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN. Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice. Mol Psychiatry. 2024 Aug;29(8):2372-2388. PDF
Wang YZ, Castillon CCM, Gebis KK, Bartom ET, d’Azzo A, Contractor A, Savas JN. Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication. Cell Rep. 2024 Feb 27;43(2):113680. PDF
Rao NR, Upadhyay A, Savas JN. Derailed protein turnover in the aging mammalian brain. Mol Syst Biol. 2024 Feb;20(2):120-139. PDF
2023
Upadhyay A, Chhangani D, Rao NR, Kofler J, Vassar R, Rincon-Limas DE, Savas JN. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Mol Neurodegener. 2023 Sep 14;18(1):61. PDF
Savas JN. The cochlea is built to last a lifetime. Hear Res. 2023 Sep 1;436:108821. PDF
Fornasiero EF, Savas JN. Determining and interpreting protein lifetimes in mammalian tissues. Trends Biochem Sci. 2023 Feb;48(2):106-118. PDF
2022
Ramirez MA, Ninoyu Y, Miller C, Andrade LR, Edassery S, Bomba-Warczak E, Ortega B, Manor U, Rutherford MA, Friedman RA, Savas JN. Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3. iScience. 2022 Jul 20;25(8):104803. PDF
Bomba-Warczak E, Savas JN. Long-lived mitochondrial proteins and why they exist. Trends Cell Biol. 2022 Aug;32(8):646-654. PDF
2021
Bomba-Warczak E, Edassery SL, Hark TJ, Savas JN. Long-lived mitochondrial cristae proteins in mouse heart and brain. J Cell Biol. 2021 Sep 6;220(9):e202005193. PDF
Rao NR, Savas JN. Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice. J Proteome Res. 2021 Jul 2;20(7):3580-3589. PDF
Hark TJ, Savas JN. Using stable isotope labeling to advance our understanding of Alzheimer’s disease etiology and pathology. J Neurochem. 2021 Oct;159(2):318-329.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O’Toole ET, Morgan GP, Ali L, Saito T, Guillermier C, Saido TC, Steinhauser ML, Stowell MHB, Chapman ER, Contractor A, Savas JN. Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. Cell Syst. 2021 Feb 17;12(2):141-158.e9. PDF
2020
Jongkamonwiwat N, Ramirez MA, Edassery S, Wong ACY, Yu J, Abbott T, Pak K, Ryan AF, Savas JN. Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network. Cell Rep. 2020 Nov 24;33(8):108431. PDF
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, Wierda KD, Savas JN, de Wit J. Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer. Nat Commun. 2020 Oct 14;11(1):5171. (Collaboration)
Graykowski DR, Wang YZ, Upadhyay A, Savas JN. The Dichotomous Role of Extracellular Vesicles in the Central Nervous System. iScience. 2020 Aug 12;23(9):101456.
2019
Liu P, Edassery SL, Ali L, Thomson BR, Savas JN, Jin J. Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry. Elife. 2019 Dec 10;8:e50170. (Collaboration)
2018
Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J. An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron. 2018 Oct 10;100(1):201-215.e9. (Collaboration)
2017
Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR 3rd. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology. Cell Rep. 2017 Nov 28;21(9):2614-2627.
Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR 3rd, Ryan AF, Savas JN. Global Analysis of Protein Expression of Inner Ear Hair Cells. J Neurosci. 2017 Feb 1;37(5):1320-1339.
2016
Savas JN, Park SK, Yates JR 3rd. Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis. Methods Mol Biol. 2016;1410:293-304.
2015
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J. The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 2015 Aug 19;87(4):764-80.